A 42 year old man who has industrial exposure to benzene, complains of fatigue and night sweats.

Question Number 0530

Question:
A 42 year old man who has industrial exposure to benzene, complains of fatigue and night sweats. On physical examination, he is found to have a low grade fever and dramatic splenomegaly. Laboratory tests are done, including a CBC with differential. His white blood count is 150,000/cu mm. His blood smear shows mature granulocytes, a few immature granulocytes and basophilia. No Auer rods are visualized. He is positive for Philadelphia chromosome. Which of the following is most likely?

a) mantle cell lymphoma
b) infectious lymphocytosis
c) Waldenstrom's macroglobulinemia
d) chronic myelogenous leukemia
e) chronic lymphoblastic leukemia


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