A 38 year old male with Down's syndrome develops shortness of breath and diffuse epistaxis.

Question Number 0017
Question:MRCP Part 1 MCQ, USMLE step 1
A 38 year old male with Down's syndrome develops shortness of breath and diffuse epistaxis. On examination he is found to have generalised large lymph nodes and hepatosplenomegaly. There are diffuse petechiae and ecchymoses, on his skin. A Romanovsky-stained smear of his bone marrow is most likely to demonstrate
a) target cells
b) melanocytes
c) lymphoblasts with clumped chromatin
d) transitional epithelial cells
e) mast cell infiltration

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