USMLE STEP 3 MCQ 47:Cardiac abnormalities are a known side effect of several cytotoxic drugs

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Question:
Cardiac abnormalities are a known side effect of several cytotoxic drugs. Which of the following cytotoxic drugs is most likely to lead to angina ?
a) fluorouracil
b) 5-fluorouracil
c) taxoids
d) cyclopentenyl cytosine
e) trastuzumab
 
Correct Answer: A
Explanation:

The cardiotoxicity which occurs in 1-2% of patients treated with fluorouracil is probably caused by coronary artery spasm. Presentations include angina, myocardial infarction, atrial fibrillation, atrial flutter, tachycardia and hypotension. A higher incidence (4.5%) occurs in patients with a history of ischaemic cardiomyopathy.


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