USMLE STEP 3 MCQ 33:Nephrotoxicity is a known side effect of several cytotoxic drugs

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Question:
Nephrotoxicity is a known side effect of several cytotoxic drugs. Which of the following cytotoxic drugs is most likely to lead to haemorrhagic cystitis ?

 

a) Cyclophosphamide
b) 5-fluorouracil
c) taxoids
d) cyclopentenyl cytosine
e) trastuzumab

 
Correct Answer: A

Explanation:


Mitomycin has been associated with the haemolytic uraemic syndrome, a syndrome of renal failure and microangiopathic haemolytic anaemia. Ifosfamide causes haematuria (it is essential to use mesna, a uroprotective agent) and a proximal tubular defect. Cyclophosphamide may cause haemorrhagic cystitis, hyponatraemia and the syndrome of inappropriate ADH secretion (SIADH)


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