Answer:USMLE step 2 Mcq 67:A 48 year old woman with a long history of headaches and depression is on long term treatment with analgesics

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Correct Answer: C
Explanation:
Long-term ingestion of large quantities of analgesics has been associated in epidemiologic studies with chronic interstitial nephritis and papillary necrosis. Because discontinuation of heavy analgesic use can slow or arrest progression of the renal disease this is an important diagnosis to make. It is a relatively common cause of chronic renal failure accounting for 10% to 20% of patients with end-stage renal disease. Analgesic nephropathy is recognized more frequently (five to seven times) in women than men. Patients typically take analgesics for chronic headaches, abdominal discomfort, or nonspecific joint pain


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