Answer:USMLE step 2 Mcq 109:A blood transfusion center in a third world country are keen to reduce the incidence of posttransfusion hepatitis C in their blood products



Correct Answer: E

The incidence of posttransfusion hepatitis C has been dramatically reduced by excluding commercially donated blood and persons at high risk of transmitting bloodborne disease as well as by screening prospective donors for evidence of HCV infection (eg, presence of anti-HCV, elevated aminotransferase). Immune globulin and HBIG are of no proven benefit in preventing transfusion-associated hepatitis C. However, some authorities recommend a single IG injection for needlestick, sexual, or perinatal exposure to hepatitis C, although efficacy has never been demonstrated and the anti-HCV in IG is not neutralizing. There is no vaccine for hepatitis C, and the acquisition of neutralizing antibody after naturally acquired hepatitis C is considered rare. Still, efforts to develop a protective vaccine based on immunization with envelope proteins is being pursued


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