USMLE step 2 Mcq 102:A fifty-five year old with chronic cardiac failure is on treatment with digoxin and a loop diuretic

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Question:
A fifty-five year old with chronic cardiac failure is on treatment with digoxin and a loop diuretic.
This combination is likely to cause digoxin toxicity by the following mechanism:

a) this combination increases the half-life of digoxin
b) diuretics decrease potassium levels
c) frusemide and digoxin interact to form a poisonous compound
d) digoxin is a competitive inhibitor of frusemide
e) the above statement is wrong, loop diuretics are not a recognised cause of increased digoxin toxicity


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