(MCQS 349-351):A pregnant woman complains of recurrent vaginal bleeding. Her fetus is small for dates at 32 weeks gestation

Correct Answer: B
When a patient in labor presents with vaginal bleeding, the physician must consider several possible causes. Placenta previa should be ruled out when a patient has copious vaginal bleeding. The classic presentation of placenta previa is painless vaginal bleeding and a soft, nontender uterus. If readily available, ultrasonography should be performed immediately, since placenta previa can be quickly and accurately diagnosed by ultrasound examination.16 When ultrasonography is not available, gentle speculum examination may be considered, as long as the bleeding is not brisk. This examination should be performed with a "double set-up" in case immediate cesarean section is required Transabdominal, transperineal and transvaginal sono-graphy (TVS) have been used to localize the placenta with variable success rates. Sonographic diagnosis of placenta previa has an excellent record of accuracy and safety. Vaginal ultrasound is the most accurate method for localizing and diagnosing placenta previa because it can utilize higher frequencies of ultrasound and provide a better resolution of the lower edge of the placenta. The patient who complains of abdominal pain between uterine contractions or a tender uterus must be presumed to have abruptio placentae. Since ultrasound examination has a high false-negative rate in diagnosing abruption, this obstetric complication is diagnosed clinically. In one prospective study,78 percent of patients with abruptio placentae presented with vaginal bleeding, 66 percent with uterine or back pain, 60 percent with fetal distress and only 17 percent with uterine contractions or hypertonus. The management of abruptio placentae is primarily supportive and entails both aggressive hydration and monitoring of maternal and fetal well-being.19 Coagulation studies should be performed, and fibrinogen and D dimers or fibrin degradation products should be measured to screen for disseminated intravascular coagulation. Packed red blood cells should be typed and held. If the fetus appears viable but compromised, urgent cesarean delivery should be considered. The presentation of uterine rupture may be similar to that of abruptio placentae. Signs and symptoms include vaginal bleeding, uterine pain and a nonreassuring fetal tracing. Uterine rupture occurs in 0.2 to 0.8 percent of vaginal birth after cesarean (VBAC) deliveries.20 In general, however, a trial of labor after previous low transverse uterine incision is safe and usually successful.21 Uterine rupture also occurs more commonly in cocaine abusers or patients who have been given high doses of oxytocin or prostaglandins. On palpation, the uterine fundus may feel boggy and tender, and it may seem to be expanding. Intrauterine pressure monitoring has not proved helpful in diagnosing uterine rupture.Treatment includes aggressive resuscitation and urgent surgical delivery. A history of abrupt onset of vaginal bleeding that began with rupture of membranes suggests vasa previa, especially when bleeding is accompanied by decreased fetal movement and a nonreassuring fetal tracing. Urgent cesarean section is generally performed. The differential diagnosis of antepartum vaginal bleeding also includes normal "bloody show" and mucopurulent cervicitis. Vasa previa should be suspected when bloody show

Correct Answer: C
Coxiella burnetii, the etiologic agent of Q fever, is a highly pleomorphic coccobacillus with a gram-negative cell wall There are three presentations of Q fever : atypical pneumonia, rapidly progressive pneumonia, and pneumonia as an incidental finding in a patient with a febrile illness. This last presentation is probably the most common form of Q fever pneumonia. In Q fever due to .Coxiella burnetii the physical examination of the chest is often unremarkable. The most common physical finding is inspiratory crackles. Patients with rapidly progressive pneumonia usually have the physical signs of pulmonary consolidation. About 5% of patients have splenomegaly. Fever and severe headache suggest central nervous system infection, and lumbar puncture is often performed.The rapidly progressive form of Q fever pneumonia mimics legionnaires' disease and the pneumonic form of tularemia, and indeed, all the causes of rapidly progressive pneumonia enter the differential diagnosis

Correct Answer: D
The major drawbacks of the AST in diagnosis of acute MI are the many conditions (especially liver congestion) that can produce AST elevation. Besides myocardial injury, the AST level may become elevated because of acute damage to parenchymal cells of the liver, skeletal muscle, kidney, and pancreas. Abnormality due to liver cell injury is especially common (e.g., liver congestion, active cirrhosis, and acute or chronic hepatitis), but an increased AST level will occur with sufficient degrees of skeletal muscle injury (including trauma or extensive surgical damage) and is also found fairly frequently in acute pancreatitis. In some of these situations, myocardial infarct may have to be considered in the differential diagnosis of the patient's symptoms


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