USMLE STEP 3 MCQ 03 : Cardiac abnormalities are a known side effect of several cytotoxic drugs.

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Question:


Cardiac abnormalities are a known side effect of several cytotoxic drugs. Which of the following cytotoxic drugs is most likely to lead tofatal ventricular dysrhythmia ?

a) Doxorubicin
b) 5-fluorouracil
c) taxoids
d) cyclopentenyl cytosine
e) trastuzumab


Your Answer: B


Explanation:
Doxorubicin may cause acute effects (within hours) including supraventricular tachyarrhythmias, ECG changes, atrial and ventricular ectopy, and, rarely, fatal ventricular dysrhythmia


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